nash-profiler (BETA 1)

Murine models are a central mechanistic platform to study fatty liver disease. In order to facilitate systematic, genome-wide mRNA expression analyses, NASH-Profiler provides data of four human and five common murine models of non-alcoholic fatty liver disease.

• Human samples
  • Healthy controls (n=39)
  • Healthy obese (n=25)
  • Non Alcoholic Fatty Liver Disease (NAFLD, n=27)
  • Non Alcoholic Steato Hepatitis (NASH, n=25)
• Murine samples
  • PTEN: Phosphatase and tensin homologue (PTEN) knock-out mice (n=3/3)
  • HF12: High fat diet with high fructose in drinking water for 12 weeks (n=4/5)
  • HF18: High fat diet with high fructose in drinking water for 18 weeks (n=5/5)
  • MCD4: methionine and choline deficient diet for 4 weeks (n=5/5)
  • MCD8: methionine and choline deficient diet for 8 weeks (n=5/5)
  • STZ12: High fat diet with high fructose in drinking water for 12 weeks plus streptozotocin injection (50 µg) at 8 weeks (n=4/5)
  • STZ 18: High fat diet with high fructose drinking water for 18 weeks plus streptozotocin injection (50 µg) at 14 weeks (n=5/5)

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